Courses with significant overlap with this course:

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Course Contents

Nomenclature of Organic molecules: (1) Brief revision, Nomenclature of polycyclic compounds including bridged, spiro and other special structures. Structure and Bonding : (2) Nature of bonding in aliphatic, ali-cyclic, aromatic and heterocyclic compounds; Aromaticity in benzenoid and non benzenoid compounds. Alternant and non alternant hydrocarbons; Dipole moment; Resonance; Inductive and Field effects, hyper conjugation, Steric inhibition of resonance, structural effects on acidity and basicity. Stereochemistry: (10) Conformational analysis of acyclic systems (Pitzer strain, A strain, etc.) and cyclohexane systems (brief review as studied in Chm 201). Introduction of terminologies such as erythro, threo, , , exo, endo, epimers, etc. Conformational analysis of decalins and other polycyclic compounds related to steroids. A brief introduction to asymmetric synthesis; Induction of chirality on a prochiral carbon atom; R and S nomenclature in (i) cyclic systems (ii) in compounds with more than one chiral centre and (iii) in biphenyls, allenes and spiro compounds. Optical isomerism in compounds without an asymmetric atom, Racemic modifications. Conformation of acyclic molecules, topicity and prostereoisomerism (topicity of legends and faces),chemical and biochemical transformations of hetero-topic legends and faces. Conformations of cyclic, fused and bridged ring compounds. Allylic strain (A1,2 and A1,3) and other strains.